| First Author | Itoh N | Year | 1990 |
| Journal | Science | Volume | 247 |
| Issue | 4940 | Pages | 324-7 |
| PubMed ID | 2404337 | Mgi Jnum | J:2991 |
| Mgi Id | MGI:51507 | Doi | 10.1126/science.2404337 |
| Citation | Itoh N, et al. (1990) Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family. Science 247(4940):324-7 |
| abstractText | Interleukin-3 (IL-3) binds to its receptor with high and low affinities, induces tyrosine phosphorylation, and promotes the proliferation and differentiation of hematopoietic cells. A binding component of the IL-3 receptor was cloned. Fibroblasts transfected with the complementary DNA bound IL-3 with a low affinity [dissociation constant (Kd) of 17.9 +/- 3.6 nM]. No consensus sequence for a tyrosine kinase was present in the cytoplasmic domain. Thus, additional components are required for a functional high affinity IL-3 receptor. A sequence comparison of the IL-3 receptor with other cytokine receptors (erythropoietin, IL-4, IL-6, and the beta chain IL-2 receptor) revealed a common motif of a distinct receptor gene family. |
