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Publication : STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases.

First Author  Howell BW Year  1991
Journal  Mol Cell Biol Volume  11
Issue  1 Pages  568-72
PubMed ID  1986248 Mgi Jnum  J:31892
Mgi Id  MGI:79394 Doi  10.1128/mcb.11.1.568
Citation  Howell BW, et al. (1991) STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases. Mol Cell Biol 11(1):568-72
abstractText  We have cloned a novel kinase (STY) from an embryonal carcinoma cell line. Sequence analysis of the STY cDNA reveals that it shares sequence homology with serine/threonine-type kinases and yet the bacterial expression product of the STY cDNA appears to have serine-, threonine-, and tyrosine-phosphorylating activities. The predicted STY protein is highly basic and contains a putative nuclear localization signal. During differentiation, two new mRNAs were detected in addition to the embryonic transcript.
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