| First Author | Seto M | Year | 1995 |
| Journal | Gene | Volume | 166 |
| Issue | 2 | Pages | 293-6 |
| PubMed ID | 8543178 | Mgi Jnum | J:30308 |
| Mgi Id | MGI:77821 | Doi | 10.1016/0378-1119(95)00559-5 |
| Citation | Seto M, et al. (1995) Cloning and expression of a murine cDNA homologous to the human RCK/P54, a lymphoma-linked chromosomal translocation junction gene on 11q23. Gene 166(2):293-6 |
| abstractText | The RCK/P54 gene was previously isolated from the chromosome translocation breakpoint region on 11q23 of a human lymphoma cell line, RC-K8, with t(11;14)(q23;q32). It was found to encode a 472-483-amino-acid (aa) polypeptide belonging to an RNA helicase/translation initiation factor family. The aim of the present investigation was the isolation and comparative sequence analysis of the mouse RCK/P54 cDNA from a BALB/c spleen cDNA library. Sequence analysis revealed an open reading frame (ORF) predicting a polypeptide of 483 aa showing 97.7% identity to human RCK/p54. Northern analysis demonstrated a 7.5-kb signal in all tissues tested and in vitro translation analysis showed a 54-kDa polypeptide. These results indicate that both mouse and human RCK/P54 are highly conserved. |
