| First Author | Dowler S | Year | 1999 |
| Journal | Biochem J | Volume | 342 ( Pt 1) |
| Pages | 7-12 | PubMed ID | 10432293 |
| Mgi Jnum | J:57026 | Mgi Id | MGI:1343578 |
| Citation | Dowler S, et al. (1999) DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. Biochem J 342(Pt 1):7-12 |
| abstractText | We have identified a novel 280 amino acid protein which contains a putative myristoylation site at its N-terminus followed by an Src homology (SH2) domain and a pleckstrin homology (PH) domain at its C-terminus. It has been termed dual adaptor for phosphotyrosine and 3-phosphoinositides (DAPP1). DAPP1 is widely expressed and exhibits high-affinity interactions with PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2), but not with other phospholipids tested. These observations predict that DAPP1 will interact with both tyrosine phosphorylated proteins and 3-phosphoinositides and may therefore play a role in regulating the location and/or activity of such proteins(s) in response to agonists that elevate PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2). |
