| First Author | Madakamutil LT | Year | 2004 |
| Journal | Science | Volume | 304 |
| Issue | 5670 | Pages | 590-3 |
| PubMed ID | 15105501 | Mgi Jnum | J:89989 |
| Mgi Id | MGI:3042090 | Doi | 10.1126/science.1092316 |
| Citation | Madakamutil LT, et al. (2004) CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors. Science 304(5670):590-3 |
| abstractText | Memory T cells are long-lived antigen-experienced T cells that are generally accepted to be direct descendants of proliferating primary effector cells. However, the factors that permit selective survival of these T cells are not well established. We show that homodimeric alpha chains of the CD8 molecule (CD8alphaalpha) are transiently induced on a selected subset of CD8alphabeta+ T cells upon antigenic stimulation. These CD8alphaalpha molecules promote the survival and differentiation of activated lymphocytes into memory CD8 T cells. Thus, memory precursors can be identified among primary effector cells and are selected for survival and differentiation by CD8alphaalpha. |
