| First Author | Bergelson JM | Year | 1997 |
| Journal | Science | Volume | 275 |
| Issue | 5304 | Pages | 1320-3 |
| PubMed ID | 9036860 | Mgi Jnum | J:87062 |
| Mgi Id | MGI:2683245 | Doi | 10.1126/science.275.5304.1320 |
| Citation | Bergelson JM, et al. (1997) Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science 275(5304):1320-3 |
| abstractText | A complementary DNA clone has been isolated that encodes a coxsackievirus and adenovirus receptor (CAR). When transfected with CAR complementary DNA, nonpermissive hamster cells became susceptible to coxsackie B virus attachment and infection. Furthermore, consistent with previous studies demonstrating that adenovirus infection depends on attachment of a viral fiber to the target cell, CAR-transfected hamster cells bound adenovirus in a fiber-dependent fashion and showed a 100-fold increase in susceptibility to virus-mediated gene transfer. Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors. |
