| First Author | Chang AC | Year | 1978 |
| Journal | Nature | Volume | 275 |
| Issue | 5681 | Pages | 617-24 |
| PubMed ID | 360074 | Mgi Jnum | J:19257 |
| Mgi Id | MGI:67444 | Doi | 10.1038/275617a0 |
| Citation | Chang AC, et al. (1978) Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase. Nature 275(5681):617-24 |
| abstractText | The construction and analysis of bacterial plasmids that contain and phenotypically express a mammalian genetic sequence are described. Such plasmids specify a protein that has enzymatic properties, immunological reactivity and molecular size characteristic of the mouse dihydrofolate reductase, and render host cells resistant to the antimetabolic drug trimethoprim. |
