First Author | Michikawa Y | Year | 1993 |
Journal | FEBS Lett | Volume | 336 |
Issue | 1 | Pages | 27-33 |
PubMed ID | 8262211 | Mgi Jnum | J:16068 |
Mgi Id | MGI:64162 | Doi | 10.1016/0014-5793(93)81602-v |
Citation | Michikawa Y, et al. (1993) Structure and organization of the gene encoding a mouse mitochondrial stress-70 protein [published erratum appears in FEBS Lett 1994 Feb 28;340(1-2):151]. FEBS Lett 336(1):27-33 |
abstractText | We have previously found that an antigenic protein specific for C3H strain mouse (C3H strain-specific antigen, CSA) is identical to peptide-binding protein 74 (PBP74). PBP74/CSA is a novel member of the stress-70 protein family in mitochondria. In this study, mouse genomic clones encoding PBP74/CSA, including the 5'- and 3'-flanking regions of the gene, have been isolated and sequenced. The PBP74/CSA gene contained 17 exons interrupted by 16 introns. Two dimeric repeats of the consensus sequence of the heat-shock element are present in the 5'-flanking region of the PBP74/CSA gene. Moreover, the first intron is interrupted within the amino-terminal leader sequence, the pattern of which is similar to that of cytochrome c1 located in the mitochondria. |