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Publication : Structure and organization of the gene encoding a mouse mitochondrial stress-70 protein.

First Author  Michikawa Y Year  1993
Journal  FEBS Lett Volume  336
Issue  1 Pages  27-33
PubMed ID  8262211 Mgi Jnum  J:16068
Mgi Id  MGI:64162 Doi  10.1016/0014-5793(93)81602-v
Citation  Michikawa Y, et al. (1993) Structure and organization of the gene encoding a mouse mitochondrial stress-70 protein [published erratum appears in FEBS Lett 1994 Feb 28;340(1-2):151]. FEBS Lett 336(1):27-33
abstractText  We have previously found that an antigenic protein specific for C3H strain mouse (C3H strain-specific antigen, CSA) is identical to peptide-binding protein 74 (PBP74). PBP74/CSA is a novel member of the stress-70 protein family in mitochondria. In this study, mouse genomic clones encoding PBP74/CSA, including the 5'- and 3'-flanking regions of the gene, have been isolated and sequenced. The PBP74/CSA gene contained 17 exons interrupted by 16 introns. Two dimeric repeats of the consensus sequence of the heat-shock element are present in the 5'-flanking region of the PBP74/CSA gene. Moreover, the first intron is interrupted within the amino-terminal leader sequence, the pattern of which is similar to that of cytochrome c1 located in the mitochondria.
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