First Author | Ferrara M | Year | 1990 |
Journal | FEBS Lett | Volume | 273 |
Issue | 1-2 | Pages | 195-9 |
PubMed ID | 2226854 | Mgi Jnum | J:10802 |
Mgi Id | MGI:59247 | Doi | 10.1016/0014-5793(90)81083-z |
Citation | Ferrara M, et al. (1990) Gene structure of mouse cathepsin B. FEBS Lett 273(1-2):195-9 |
abstractText | The structure of a genomic DNA fragment encoding mouse cathepsin B was characterized. The genomic insert spans 15 kbp and contains 9 exons encoding the 339 amino acid residues of mouse preprocathepsin B. Intron break-points are not found at the junctions of the pre-peptide, pro-peptide and mature enzyme. Like other cysteine proteinase genes, the region around the cysteinyl active site is split by an intron, but in contrast with cathepsins L and H the intron break-point is located immediately after the active site. |