| First Author | Park LS | Year | 2000 |
| Journal | J Exp Med | Volume | 192 |
| Issue | 5 | Pages | 659-70 |
| PubMed ID | 10974032 | Mgi Jnum | J:64302 |
| Mgi Id | MGI:1889078 | Doi | 10.1084/jem.192.5.659 |
| Citation | Park LS, et al. (2000) Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. J Exp Med 192(5):659-70 |
| abstractText | The cellular receptor for murine thymic stromal lymphopoietin (TSLP) was detected in a variety of murine, but not human myelomonocytic cell lines by radioligand binding. cDNA clones encoding the receptor were isolated from a murine T helper cell cDNA library. TSLP receptor (TSLPR) is a member of the hematopoietin receptor family. Transfection of TSLPR cDNA resulted in only low affinity binding. Cotransfection of the interleukin 7 (IL-7)Ralpha chain cDNA resulted in conversion to high affinity binding. TSLP did not activate cells from IL-7Ralpha(-/)- mice, but did activate cells from gammac(-/)- mice. Thus, the functional TSLPR requires the IL-7Ralpha chain, but not the gammac chain for signaling. |
