| First Author | Nishizawa M | Year | 1992 |
| Journal | FEBS Lett | Volume | 299 |
| Issue | 1 | Pages | 36-8 |
| PubMed ID | 1371974 | Mgi Jnum | J:2973 |
| Mgi Id | MGI:51489 | Doi | 10.1016/0014-5793(92)80094-w |
| Citation | Nishizawa M, et al. (1992) cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein. FEBS Lett 299(1):36-8 |
| abstractText | The gene expression of granulocyte colony-stimulating factor (G-CSF) is induced by lipopolysaccharide (LPS). GPE1, a cis-controlling element of the G-CSF gene, functions as an LPS-responsive element. GPE1-binding protein (GPE1-BP), a leucine-zipper protein, did not independently activate G-CSF gene expression. Protein blot analysis with biotinylated GPE1-BP revealed that there were nuclear proteins that interact specifically with GPE1-BP. Three leucine-zipper proteins were isolated from mouse cDNA expression libraries by this method: NF-IL6, ATF4, and a novel ATF4-related ATFx. The interactions of these proteins with GPE1-BP may play key roles in G-CSF gene expression. |
