| First Author | Kumaki S | Year | 1993 |
| Journal | Biochem Biophys Res Commun | Volume | 193 |
| Issue | 1 | Pages | 356-63 |
| PubMed ID | 8503926 | Mgi Jnum | J:12198 |
| Mgi Id | MGI:60448 | Doi | 10.1006/bbrc.1993.1631 |
| Citation | Kumaki S, et al. (1993) Cloning of the mouse interleukin 2 receptor gamma chain: demonstration of functional differences between the mouse and human receptors. Biochem Biophys Res Commun 193(1):356-63 |
| abstractText | We isolated a cDNA clone for the gamma chain of the mouse interleukin 2 receptor. Introduction of the mouse gamma chain cDNA clone into a mouse fibroblast cell line, L929, expressing the mouse alpha beta heterodimer IL-2 receptor converted pseudo-high affinity of the IL-2 receptor into functional high, resulting in internalization of IL-2 and induction of the c-myc, c-fos and c-jun genes. The mouse beta gamma heterodimer, however, failed to bind IL-2 unlike the human beta gamma heterodimer intermediate-affinity receptor. These results indicate that the mouse functional IL-2 receptor is a complex comprising three distinct subunits, alpha, beta and gamma chains, but the beta gamma heterodimer is not functional and different from the human heterodimer. |
