| First Author | Kinzig A | Year | 1997 |
| Journal | FEBS Lett | Volume | 402 |
| Issue | 2-3 | Pages | 162-6 |
| PubMed ID | 9037187 | Mgi Jnum | J:38334 |
| Mgi Id | MGI:85709 | Doi | 10.1016/s0014-5793(96)01517-7 |
| Citation | Kinzig A, et al. (1997) Murine epidermal lipoxygenase (Aloxe) encodes a 12-lipoxygenase isoform. FEBS Lett 402(2-3):162-6 |
| abstractText | Using a combination of conventional screening procedures and polymerase chain reaction cloning, we have isolated a cDNA encoding an epidermis-type 12-lipoxygenase (e12- lipoxygenase) from mouse epidermis. The open reading frame corresponds to a protein of 662 amino acids and was found to be 99.8% identical to the ORF of an epidermal lipoxygenase gene Aloxe, described recently [Van Dijk et al. (1995) Biochim. Biophys. Acta 1259, 4-8]. When expressed in human embryonic kidney cells the recombinant protein could be shown to synthesize 12(S)-HETE from arachidonic acid. By fluorescence in situ hybridization the e12-lipoxygenase gene was localized to chromosome band 11 B1-B3. |
