| First Author | Deák F | Year | 1999 |
| Journal | Cytogenet Cell Genet | Volume | 87 |
| Issue | 1-2 | Pages | 75-9 |
| PubMed ID | 10640815 | Mgi Jnum | J:59118 |
| Mgi Id | MGI:1351050 | Doi | 10.1159/000015395 |
| Citation | Deak F, et al. (1999) Characterization and chromosome location of the mouse link protein gene (Crtl1). Cytogenet Cell Genet 87(1-2):75-9 |
| abstractText | Link protein (LP) plays an essential role in endochondral bone formation by stabilizing the supramolecular assemblies of aggrecan and hyaluronan. We have isolated and characterized the mouse link protein gene (Crtl1). It is longer than 40 kb and transcribed from two alternative promoters, leading to heterogeneous mRNAs between 5.3 and 1.3 kb in size. Apart from the coding sequence, the 5' flanking region is also highly conserved in mammals. Immunostaining revealed high levels of LP expression in the cartilaginous primordia of skeletal elements and low levels in other tissues. Using single-strand conformation polymorphism analysis, Crtl1 was assigned to mouse chromosome 13, tightly linked to Dhfr. Copyright 1999 S. Karger AG, Basel |
