| First Author | Carlyle JR | Year | 1999 |
| Journal | J Immunol | Volume | 162 |
| Issue | 10 | Pages | 5917-23 |
| PubMed ID | 10229828 | Mgi Jnum | J:54974 |
| Mgi Id | MGI:1336837 | Doi | 10.4049/jimmunol.162.10.5917 |
| Citation | Carlyle JR, et al. (1999) Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function. J Immunol 162(10):5917-23 |
| abstractText | The mouse NK1.1 Ag originally defined as NK cell receptor (NKR)-P1C (CD161) mediates NK cell activation. Here, we show that another member of the mouse CD161 family, NKR-P1B, represents a novel NK1.1 Ag. In contrast to NKR-P1C, which functions as an activating receptor, NKR-P1B inhibits NK cell activation. Association of NKR-P1B with Src homology 2-containing protein tyrosine phosphatase-1 provides a molecular mechanism for this inhibition. The existence of these two NK1.1 Ags with opposite functions suggests a potential role for NKR-P1 molecules, such as those of the Ly-49 gene family, in regulating NK cell function. |
