| First Author | Brown J | Year | 1998 |
| Journal | Leukemia | Volume | 12 |
| Issue | 11 | Pages | 1771-81 |
| PubMed ID | 9823953 | Mgi Jnum | J:50847 |
| Mgi Id | MGI:1312963 | Doi | 10.1038/sj.leu.2401164 |
| Citation | Brown J, et al. (1998) Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase. Leukemia 12(11):1771-81 |
| abstractText | Through differential screening of established human leukaemia cell lines, we have identified and molecularly cloned lymphopain, a novel cysteine proteinase of the papain family. Lymphopain exhibits a remarkably restricted cellular pattern of expression, being predominantly expressed in cytotoxic T-lymphocytes and natural killer cells. The human lymphopain locus maps to chromo- some 11q13, encodes a polypeptide of 376 amino acids and is conserved in the mouse. Both human and murine forms appear more closely related to protozoan papain-like enzymes than to other mammalian members of the papain family. The cellular distribution of lymphopain expression, together with the functional demonstration of lymphopain-associated proteinase activity in vitro, is suggestive of a role for lymphopain in immune cell-mediated, cell killing. |
