| First Author | Threadgill DW | Year | 1995 |
| Journal | Science | Volume | 269 |
| Issue | 5221 | Pages | 230-4 |
| PubMed ID | 7618084 | Mgi Jnum | J:26833 |
| Mgi Id | MGI:74263 | Doi | 10.1126/science.7618084 |
| Citation | Threadgill DW, et al. (1995) Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269(5221):230-4 |
| abstractText | Gene targeting was used to create a null allele at the epidermal growth factor receptor locus (Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 background resulted in peri-implantation death due to degeneration of the inner cell mass. On a 129/Sv background, homozygous mutants died at mid-gestation due to placental defects; on a CD-1 background, the mutants lived for up to 3 weeks and showed abnormalities in skin, kidney, brain, liver, and gastrointestinal tract. The multiple abnormalities associated with EGFR deficiency indicate that the receptor is involved in a wide range of cellular activities. |
