| First Author | Blechynden LM | Year | 1996 |
| Journal | Gene | Volume | 178 |
| Issue | 1-2 | Pages | 151-6 |
| PubMed ID | 8921907 | Mgi Jnum | J:36427 |
| Mgi Id | MGI:83857 | Doi | 10.1016/0378-1119(96)00358-7 |
| Citation | Blechynden LM, et al. (1996) Sequence and polymorphism analysis of the murine gene encoding histidyl-tRNA synthetase. Gene 178(1-2):151-6 |
| abstractText | The murine histidyl-tRNA synthetase-encoding gene (MMHRS) coding region has been cloned and sequenced. The 1527-bp transcript shows a strikingly similar structural organization to that of its human counterpart, particularly within the three class II aminoacyl-tRNA synthetase structural motifs and the two histidyl-tRNA synthetase signature regions. It is predicted, as in humans, to have a coiled-coil alpha-helical structure that is characteristic of many autoantigens. MMHRS shows some degree of polymorphism at both the DNA and amino-acid levels, although its sequence is well conserved amongst the commonly used laboratory mouse strains. |
