| First Author | Chen LT | Year | 1999 |
| Journal | J Biol Chem | Volume | 274 |
| Issue | 38 | Pages | 26931-8 |
| PubMed ID | 10480904 | Mgi Jnum | J:57578 |
| Mgi Id | MGI:1344968 | Doi | 10.1074/jbc.274.38.26931 |
| Citation | Chen LT, et al. (1999) A candidate target for G protein action in brain. J Biol Chem 274(38):26931-8 |
| abstractText | An effector candidate for G protein action, GRIN1, was identified by screening a cDNA expression library with phosphorylated GTPgammaS-G(z)alpha as a probe. GRIN1 is a novel protein without substantial homology to known protein domains. It is expressed largely in brain and binds specifically to activated G(z)alpha, G(o)alpha, and G(i)alpha through its carboxyl-terminal region. The protein KIAA0514 (GRIN2) is homologous to GRIN1 at its carboxyl terminus and also binds to activated G(o)alpha. Both GRIN1 and G(o)alpha are membrane-bound proteins that are enriched in the growth cones of neurites. Coexpression of GRIN1 or GRIN2 with activated G(o)alpha causes formation of a network of fine processes in Neuro2a cells, suggesting that these pathways may function downstream of G(o)alpha to control growth of neurites. |
