| First Author | Xu P | Year | 2006 |
| Journal | Cell Immunol | Volume | 240 |
| Issue | 2 | Pages | 116-21 |
| PubMed ID | 16934789 | Mgi Jnum | J:112852 |
| Mgi Id | MGI:3663835 | Doi | 10.1016/j.cellimm.2006.07.004 |
| Citation | Xu P, et al. (2006) The role of grancalcin in adhesion of neutrophils. Cell Immunol 240(2):116-21 |
| abstractText | Grancalcin is a protein specifically expressed in neutrophils and monocytes/macrophages. The function of grancalcin has not been identified. Grancalcin-deficient neutrophils were previously demonstrated to exert normal recruitment to the inflamed site, NADPH oxidase activation, extracellular release of secondary granules, apoptosis and activation-induced Ca2+ flux. In this study we analyzed granule numbers in resting and activated grancalcin-deficient neutrophils, their phagocytic activity and adherence to extracellular matrix proteins. Results revealed normal phagocytosis and degranulation of grancalcin-deficient neutrophils, while their adhesion to fibronectin was decreased by 60%. Consistently, the processes associated with neutrophil adhesion, such as formation of focal adhesion complexes and spreading, were also impaired in grancalcin-deficient neutrophils by 89 and 38%, respectively. In contrast, adherence to other extracellular matrix proteins: collagen, laminin and vitronectin, was not significantly altered. We thus report for the first time a function of grancalcin. |
