| First Author | Yasojima K | Year | 1997 |
| Journal | Biochem Biophys Res Commun | Volume | 231 |
| Issue | 2 | Pages | 481-7 |
| PubMed ID | 9070305 | Mgi Jnum | J:38480 |
| Mgi Id | MGI:85863 | Doi | 10.1006/bbrc.1996.6033 |
| Citation | Yasojima K, et al. (1997) Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus. Biochem Biophys Res Commun 231(2):481-7 |
| abstractText | We identified a novel gene, kf-1, highly expressed in the normal cerebellum but not in the cerebral cortex, the expression of which could have been augmented in the cerebral cortex of a sporadic Alzheimer's disease patient. We cloned human and mouse entire kf-1 cDNAs encoding conserved 79 kDa proteins containing a zinc-binding RING- H2 finger motif at the carboxy-terminus as found in acetylcholine receptor-associated protein (RAPsyn). The 3'- untranslated regions are highly conserved between human and mouse as to constitute a common mRNA secondary structure. In situ hybridization analysis of mouse brain sections revealed strong Kf-1 expression in the cerebellum and hippocampus. We propose that kF-1 is involved in membranous protein-sorting apparatus similarly to RAPsyn. We mapped the human kf-1 gene to 2p11.2. (C) 1997 Academic Press. |
