| First Author | Kawakami T | Year | 1995 |
| Journal | FEBS Lett | Volume | 358 |
| Issue | 3 | Pages | 225-9 |
| PubMed ID | 7843405 | Mgi Jnum | J:22857 |
| Mgi Id | MGI:70745 | Doi | 10.1016/0014-5793(94)01426-2 |
| Citation | Kawakami T, et al. (1995) Possible involvement of the transcription factor ISGF3 gamma in virus-induced expression of the IFN-beta gene. FEBS Lett 358(3):225-9 |
| abstractText | Two virus-inducible transcription factors, IRF-1 and IRF-2 have been identified as an activator and a repressor, respectively, of the type I interferon (IFN) genes. Recent studies with mice carrying null mutations for the IRF-1 or IRF-2 alleles have revealed the existence of IRF-1-dependent and -independent pathways mediating IFN-beta gene induction. Here we report that the expression of an IRF family member ISGF3 gamma is induced upon viral infection in IRF-1-/-, IRF-2-/- embryonic fibroblasts. Furthermore, ISGF3 gamma can bind to a virus-inducible promoter element in the IFN-beta gene. These results suggest that ISGF3 gamma or complex containing ISGF3 gamma is involved in the IRF-1-independent pathway mediating IFN-beta gene regulation. |
