| First Author | Newman DM | Year | 2017 |
| Journal | J Leukoc Biol | Volume | 101 |
| Issue | 4 | Pages | 887-892 |
| PubMed ID | 27733580 | Mgi Jnum | J:285029 |
| Mgi Id | MGI:6393224 | Doi | 10.1189/jlb.1MA0816-338R |
| Citation | Newman DM, et al. (2017) Essential role for the histone acetyltransferase KAT7 in T cell development, fitness, and survival. J Leukoc Biol 101(4):887-892 |
| abstractText | Histone acetylation has an important role in gene regulation, DNA replication, and repair. Because these processes are central to the development of the immune system, we investigated the role of a previously unstudied histone acetyltransferase named KAT7 (also known as Myst2 or HBO1) in the regulation of thymopoiesis and observed a critical role in the regulation of conventional and innate-like T cell development. We found that KAT7-deficient thymocytes displayed normal, positive selection and development into mature single-positive alphabeta thymocytes; however, we observed few peripheral CD4(+) or CD8(+) T cells. The observed effects did not appear to arise from alterations to DNA replication, the TCR repertoire, or a block in thymocyte maturation and, more likely, was linked to survival defects related to gene deregulation because KAT7 deficiency led to an almost complete and specific loss of global histone-H3 lysine 14 acetylation (H3K14ac). Overall, we demonstrated a nonredundant role for KAT7 in the maintenance of H3K14ac, which is intimately linked with the ability to develop a normal immune system. |
