| First Author | Haziot A | Year | 1996 |
| Journal | Immunity | Volume | 4 |
| Issue | 4 | Pages | 407-14 |
| PubMed ID | 8612135 | Mgi Jnum | J:32729 |
| Mgi Id | MGI:80217 | Doi | 10.1016/s1074-7613(00)80254-x |
| Citation | Haziot A, et al. (1996) Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity 4(4):407-14 |
| abstractText | Endotoxin shock is the result of activation of the immune system by endotoxin/LPS, a component of Gram-negative bacteria. CD14, a GPI-anchored glycoprotein expressed strongly by monocyte/macrophages, is one of several receptors for endotoxin/LPS. The role of CD14 in bacterial-induced and LPS-induced shock was tested in CD14-deficient mice produced by gene targeting in embryonic stem cells. CD14-deficient mice were found to be highly resistant to shock induced by either live Gram-negative bacteria or LPS; however, at very high concentrations of LPS or bacteria, responses through non-CD14 receptors could be detected. Surprisingly, CD14-deficient mice also showed dramatically reduced levels of bacteremia, suggesting an unexpected role for CD14 in the dissemination of Gram-negative bacteria. |
