| First Author | Pagliarini DJ | Year | 2005 |
| Journal | Mol Cell | Volume | 19 |
| Issue | 2 | Pages | 197-207 |
| PubMed ID | 16039589 | Mgi Jnum | J:354161 |
| Mgi Id | MGI:7731040 | Doi | 10.1016/j.molcel.2005.06.008 |
| Citation | Pagliarini DJ, et al. (2005) Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Mol Cell 19(2):197-207 |
| abstractText | Reversible phosphorylation is the cell's most prevalent form of posttranslational modification, yet its role in the regulation of mitochondrial functions is poorly understood. We have discovered that a member of the dual-specific protein tyrosine phosphatase (DS-PTP) family, PTPMT1 (PTP localized to the Mitochondrion 1) resides nearly exclusively in mitochondria. PTPMT1 is targeted to the mitochondrion by an N-terminal signal sequence and is found anchored to the matrix face of the inner membrane. Knockdown of PTPMT1 expression in the pancreatic insulinoma cell line INS-1 832/13 alters the mitochondrial phosphoprotein profile and markedly enhances both ATP production and insulin secretion. These data define PTPMT1 as a potential drug target for the treatment of type II diabetes and strengthen the notion that mitochondria are an underappreciated site of signaling by reversible phosphorylation. |
