| First Author | Raghunathan A | Year | 2001 |
| Journal | Exp Cell Res | Volume | 268 |
| Issue | 2 | Pages | 230-44 |
| PubMed ID | 11478849 | Mgi Jnum | J:114034 |
| Mgi Id | MGI:3688044 | Doi | 10.1006/excr.2001.5290 |
| Citation | Raghunathan A, et al. (2001) Functional analysis of B144/LST1: a gene in the tumor necrosis factor cluster that induces formation of long filopodia in eukaryotic cells. Exp Cell Res 268(2):230-44 |
| abstractText | B144/LST1 is a gene encoded in the human major histocompatibility complex that produces multiple forms of alternatively spliced mRNA and encodes peptides fewer than 100 amino acids in length. B144/LST1 is strongly expressed in dendritic cells. Transfection of B144/LST1 into a variety of cells induces morphologic changes including the production of long, thin filopodia differing from those seen on transfection of a dominant active CDC42 gene. The structures are dynamically rearranging and sometimes connect one cell with another. The full effect of B144/LST1 protein on cell morphology requires the retention of at least one of the four cysteines of the peptide plus the presence of a hydrophobic segment in the protein, but requires only one of the two coding regions present in the terminal 3' exons. |
