| First Author | Prendergast GC | Year | 1990 |
| Journal | Mol Cell Biol | Volume | 10 |
| Issue | 3 | Pages | 1265-9 |
| PubMed ID | 2406566 | Mgi Jnum | J:32471 |
| Mgi Id | MGI:79967 | Doi | 10.1128/mcb.10.3.1265 |
| Citation | Prendergast GC, et al. (1990) The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1. Mol Cell Biol 10(3):1265-9 |
| abstractText | The DNA sequence of the c-myc-regulated gene mrl (G. C. Prendergast and M. D. Cole, Mol. Cell. Biol. 9:124-134, 1989) reveals that it encodes plasminogen activator inhibitor 1 (PAI-1), a regulator of extracellular proteolysis. Comparison of the human and mouse PAI-1 promoters and cDNA 3' noncoding regions revealed several highly conserved sequence domains, potential targets for c-myc and other factors influencing PAI-1 expression. We discuss possible roles for PAI-1 in normal and neoplastic cell growth control. |
