| First Author | Li S | Year | 1990 |
| Journal | Nature | Volume | 347 |
| Issue | 6293 | Pages | 528-33 |
| PubMed ID | 1977085 | Mgi Jnum | J:10774 |
| Mgi Id | MGI:59219 | Doi | 10.1038/347528a0 |
| Citation | Li S, et al. (1990) Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature 347(6293):528-33 |
| abstractText | Mutations at the mouse dwarf locus (dw) interrupt the normal development of the anterior pituitary gland, resulting in the loss of expression of growth hormone, prolactin and thyroid-stimulating hormone, and hypoplasia of their respective cell types. Disruptions in the gene encoding the POU-domain transcription factor, Pit-1, occur in both characterized alleles of the dwarf locus. The data indicate that Pit-1 is necessary for the specification of the phenotype of three cell types in the anterior pituitary, and directly link a transcription factor to commitment and progression events in mammalian organogenesis. |
