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Publication : Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene.

First Author  McDonald JD Year  1986
Journal  Mol Cell Biol Volume  6
Issue  3 Pages  842-8
PubMed ID  3022133 Mgi Jnum  J:8454
Mgi Id  MGI:56920 Doi  10.1128/mcb.6.3.842
Citation  McDonald JD, et al. (1986) Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene. Mol Cell Biol 6(3):842-8
abstractText  The gene for mouse erythropoietin was cloned and sequenced. We present here a preliminary analysis of the overall genomic organization of the coding portions and the two flanking regions of the gene. This is the third mammalian erythropoietin for which the sequence is available, but it represents the first from a nonprimate species. We investigated the evolutionary divergence of sequence and structure of the three erythropoietins and identified specific regions of the molecules that are apparently under various degrees, and perhaps different types, of functional constraint.
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