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Publication : Interaction of RhoD and ZIP kinase modulates actin filament assembly and focal adhesion dynamics.

First Author  Nehru V Year  2013
Journal  Biochem Biophys Res Commun Volume  433
Issue  2 Pages  163-9
PubMed ID  23454120 Mgi Jnum  J:201236
Mgi Id  MGI:5512821 Doi  10.1016/j.bbrc.2013.02.046
Citation  Nehru V, et al. (2013) Interaction of RhoD and ZIP kinase modulates actin filament assembly and focal adhesion dynamics. Biochem Biophys Res Commun 433(2):163-9
abstractText  RhoD is a member of the classical Rho GTPases and it has an essential role in the regulation of actin dynamics. Furthermore, RhoD also localizes to early endosomes and recycling endosomes, indicating additional roles in the regulation of endosome trafficking. A yeast two-hybrid screen identified Zipper-Interacting Protein Kinase (ZIPK) as a RhoD target. We found that RhoD interacts with ZIP kinase in a GTP dependent manner and modulates actin and focal adhesion reorganization. Interestingly, while ectopic expression of ZIPK in fibroblasts induces actin reorganization and actomyosin contraction seen as stress fiber bundling and membrane blebbing, the concomitant expression of active RhoD suppressed this phenotype. Previously, RhoD has been associated with focal adhesion regulation, and in line with this notion, we observed that ZIPK resulted in reorganization of focal adhesion and increased adhesion size. Importantly, the RhoD activity suppressed ZIPK-dependent effects on FAK activity, indicating a functional interplay between RhoD and FAK in the focal adhesion dynamics.
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