| First Author | Touré A | Year | 2004 |
| Journal | Genomics | Volume | 83 |
| Issue | 1 | Pages | 140-7 |
| PubMed ID | 14667817 | Mgi Jnum | J:87205 |
| Mgi Id | MGI:2683872 | Doi | 10.1016/s0888-7543(03)00216-7 |
| Citation | Toure A, et al. (2004) A protein encoded by a member of the multicopy Ssty gene family located on the long arm of the mouse Y chromosome is expressed during sperm development. Genomics 83(1):140-7 |
| abstractText | Multicopy Y-chromosomal genes in human and mouse have been postulated to play a role in spermatogenesis. The mouse Y long arm (Yq) carries hundreds of supposedly intronless copies of Ssty, for which no protein has hitherto been identified; mice lacking Yq are sterile with grossly abnormal sperm. We have now identified an Ssty-encoded protein (Ssty1) that is expressed in spermatids. The protein is absent from spermatids of mice that lack Yq, but is not reduced in mice with a two-thirds reduction of Ssty copies, implying that most do not produce this protein. Furthermore, no protein was produced by a strongly transcribed intronless Ssty transgene, raising doubts as to the protein-encoding potential of these intronless genes. We have now identified an intron-containing copy that is also present in multiple copies on Yq. One or more intron-containing copies are retained in the Ssty-deficient mice and may be the source of the Ssty1 protein. |
