| First Author | Seither P | Year | 1996 |
| Journal | Genomics | Volume | 37 |
| Issue | 1 | Pages | 135-9 |
| PubMed ID | 8921381 | Mgi Jnum | J:35801 |
| Mgi Id | MGI:83246 | Doi | 10.1006/geno.1996.0531 |
| Citation | Seither P, et al. (1996) Molecular cloning of RPA2, the gene encoding the second largest subunit of mouse RNA polymerase I. Genomics 37(1):135-9 |
| abstractText | We have cloned the cDNA encoding the second largest subunit of RNA polymerase I, termed RPA2, from mouse cells. The cDNA has a 3978-nucleotide open reading frame encoding a polypeptide of 1136 amino acids with a calculated molecular mass of 128 kDa. A sequence alignment of mouse RPA2 with the corresponding gene from Drosophila melanogaster and yeast reveals a much lower sequence similarity of this subunit of RNA polymerase I (Pol I) compared to the second largest subunit of other eukaryotic RNA polymerases. Four Pol I-specific regions, termed I alpha-I delta, are conserved in the N-terminal part of RPA2. The structural features of the different domains as well as the homology to essential functional domains found in other RNA polymerases are discussed. |
