| First Author | Yan M | Year | 2000 |
| Journal | Nat Immunol | Volume | 1 |
| Issue | 1 | Pages | 37-41 |
| PubMed ID | 10881172 | Mgi Jnum | J:64472 |
| Mgi Id | MGI:1889351 | Doi | 10.1038/76889 |
| Citation | Yan M, et al. (2000) Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nat Immunol 1(1):37-41 |
| abstractText | B lymphocyte stimulator (BLyS) is a member of the tumor necrosis factor (TNF) superfamily. BLyS stimulates proliferation of, and immunoglobulin production by, B cells. However, the relative importance of BLyS in physiological B cell activation is unclear. We identified a B cell receptor for BLyS through expression cloning as TACI, an orphan TNF receptor homologue of unknown function. Binding of BLyS to TACI activated signaling by nuclear factor-kappa B (NF-kappa B). In vitro soluble TACI-Fc fusion protein blocked BLyS-induced NF-kappa B activation in B lymphoma cells and IgM production in peripheral blood B cells. In vivo treatment of immunized mice with TACI-Fc inhibited production of antigen-specific IgM and IgGI antibodies and abolished splenic germinal center (GC) formation. Thus, BLyS activity must play a critical role in the humoral immune response. |
