| First Author | Dron M | Year | 1998 |
| Journal | J Biol Chem | Volume | 273 |
| Issue | 29 | Pages | 18015-8 |
| PubMed ID | 9660755 | Mgi Jnum | J:48683 |
| Mgi Id | MGI:1274865 | Doi | 10.1074/jbc.273.29.18015 |
| Citation | Dron M, et al. (1998) Characterization of the human analogue of a Scrapie-responsive gene. J Biol Chem 273(29):18015-8 |
| abstractText | We have recently described a novel mRNA denominated ScRG-1, the level of which is increased in the brains of Scrapie-infected mice (Dandoy-Dron, F., Guillo, F., Benboudjema, L., Deslys, J.-P., Lasmezas, C., Dormont, D., Tovey, M. G., and Dron, M. (1998) J. Biol. Chem. 273, 7691-7697). The increase in ScRG-1 mRNA in the brain follows the accumulation of PrPSc, the proteinase K-resistant form of the prion protein (PrP), and precedes the widespread neuronal death that occurs in late stage disease. In the present study, we have isolated a cDNA encoding the human counterpart of ScRG-1. Comparison of the human and mouse transcripts firmly established that both sequences encode a highly conserved protein of 98 amino acids that contains a signal peptide, suggesting that the protein may be secreted. Examination of the distribution of human ScRG-1 mRNA in adult and fetal tissues revealed that the gene was expressed primarily in the central nervous system as a 0.7-kilobase message and was under strict developmental control. |
