| First Author | Bonnert TP | Year | 1997 |
| Journal | FEBS Lett | Volume | 402 |
| Issue | 1 | Pages | 81-4 |
| PubMed ID | 9013863 | Mgi Jnum | J:38114 |
| Mgi Id | MGI:85501 | Doi | 10.1016/s0014-5793(96)01506-2 |
| Citation | Bonnert TP, et al. (1997) The cloning and characterization of human MyD88: A member of an IL-1 receptor related family. FEBS Lett 402(1):81-84 |
| abstractText | Murine MyD88, an RNA with homology both to the interleukin- 1 receptor signaling domain and to 'death-domains', is rapidly upregulated during differentiation of the myeloleukemic cell line M1, We have cloned the human homologue of murine MyD88 and re-evaluated the murine sequence. The open reading frame for both species encodes a 296 amino acid protein, which for murine MyD88 is 53 amino acids longer than originally published, Human MyD88 cDNA is encoded by 5 exons, and maps to chromosome 3p21.3- p22 by fluorescence in situ hybridination (FISH), Overexpression of the death domain region leads to transcriptional activation of the IL-8 promoter. |
