| First Author | Hodge MR | Year | 1996 |
| Journal | Science | Volume | 274 |
| Issue | 5294 | Pages | 1903-5 |
| PubMed ID | 8943202 | Mgi Jnum | J:51755 |
| Mgi Id | MGI:1326822 | Doi | 10.1126/science.274.5294.1903 |
| Citation | Hodge MR, et al. (1996) NF-AT-Driven interleukin-4 transcription potentiated by NIP45. Science 274(5294):1903-5 |
| abstractText | The induction of cytokine gene transcription is mediated in part by the nuclear factor of activated T cells (NF-AT). Factors involved in the mechanisms of NF-AT-mediated transcription are not well understood. A nuclear factor that interacted with the Rel homology domain (RHD) of NF- ATp was identified with the use of a two-hybrid interaction trap. Designated NIP45 (NF-AT interacting protein), it has minimal similarity to any known genes. Transcripts encoding this factor were enriched in lymphoid tissues and testes. NIP45 synergized with NF-ATp and the proto- oncogene c-Maf to activate the interleukin-4 (IL-4) cytokine promoter; transient overexpression of NIP45 with NF-ATp and c-maf in B lymphoma cells induced measurable endogenous IL-4 protein production. The identification of NIP45 advances our understanding of gene activation of cytokines, critical mediators of the immune response. |
