First Author | Liu Q | Year | 1997 |
Journal | Genomics | Volume | 39 |
Issue | 1 | Pages | 109-12 |
PubMed ID | 9027494 | Mgi Jnum | J:37834 |
Mgi Id | MGI:85230 | Doi | 10.1006/geno.1996.4374 |
Citation | Liu Q, et al. (1997) Molecular cloning and chromosomal localization in human and mouse of the SH2-containing inositol phosphatase, INPP5D (SHIP). Amgen EST Program. Genomics 39(1):109-12 |
abstractText | The action of lipid phosphatases on inositol phosphates is thought to be one method that the cell uses to attenuate growth factor- or cytokine-induced mobilization of calcium. We have cloned a cDNA from a mouse spleen library that is virtually identical to the recently described inositol tetraphosphate and phosphatidylinositol 3,4,5- trisphosphate 5-phosphatase, SHIP. Chromosomal localization studies in human and mouse by FISH mapping and interspecies backcrossing in mice have demonstrated that human SHIP is localized to 2q36-q37.1 and that mouse SHIP is localized to 1C5. (C) 1997 Academic Press |