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Publication : Molecular cloning and chromosomal localization in human and mouse of the SH2-containing inositol phosphatase, INPP5D (SHIP). Amgen EST Program.

First Author  Liu Q Year  1997
Journal  Genomics Volume  39
Issue  1 Pages  109-12
PubMed ID  9027494 Mgi Jnum  J:37834
Mgi Id  MGI:85230 Doi  10.1006/geno.1996.4374
Citation  Liu Q, et al. (1997) Molecular cloning and chromosomal localization in human and mouse of the SH2-containing inositol phosphatase, INPP5D (SHIP). Amgen EST Program. Genomics 39(1):109-12
abstractText  The action of lipid phosphatases on inositol phosphates is thought to be one method that the cell uses to attenuate growth factor- or cytokine-induced mobilization of calcium. We have cloned a cDNA from a mouse spleen library that is virtually identical to the recently described inositol tetraphosphate and phosphatidylinositol 3,4,5- trisphosphate 5-phosphatase, SHIP. Chromosomal localization studies in human and mouse by FISH mapping and interspecies backcrossing in mice have demonstrated that human SHIP is localized to 2q36-q37.1 and that mouse SHIP is localized to 1C5. (C) 1997 Academic Press
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