| First Author | Fremeau RT Jr | Year | 2004 |
| Journal | Science | Volume | 304 |
| Issue | 5678 | Pages | 1815-9 |
| PubMed ID | 15118123 | Mgi Jnum | J:105647 |
| Mgi Id | MGI:3616153 | Doi | 10.1126/science.1097468 |
| Citation | Fremeau RT Jr, et al. (2004) Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites. Science 304(5678):1815-9 |
| abstractText | Vesicular glutamate transporters (VGLUTs) 1 and 2 show a mutually exclusive distribution in the adult brain that suggests specialization for synapses with different properties of release. Consistent with this distribution, inactivation of the VGLUT1 gene silenced a subset of excitatory neurons in the adult. However, the same cell populations exhibited VGLUT1-independent transmission early in life. Developing hippocampal neurons transiently coexpressed VGLUT2 and VGLUT1 at distinct synaptic sites with different short-term plasticity. The loss of VGLUT1 also reduced the reserve pool of synaptic vesicles. Thus, VGLUT1 plays an unanticipated role in membrane trafficking at the nerve terminal. |
