| First Author | Mine T | Year | 2000 |
| Journal | Tissue Antigens | Volume | 55 |
| Issue | 5 | Pages | 429-36 |
| PubMed ID | 10885563 | Mgi Jnum | J:63557 |
| Mgi Id | MGI:1861177 | Doi | 10.1034/j.1399-0039.2000.550505.x |
| Citation | Mine T, et al. (2000) CDw108 expression during T-cell development. Tissue Antigens 55(5):429-36 |
| abstractText | We recently reported a gene encoding the human CDw108, a glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein that is preferentially expressed on activated T lymphocytes and erythrocytes. The present study investigated the expression of CDw108 on various tissues and cells, particularly on T cells during development. The murine CDw108 cDNA was cloned initially, and it was highly homologous to the human CDw108 (88.0% or 89.3% similarity at the nucleotide or amino acid level, respectively) or identical to the murine semaphorin K1/Sema7A. The CDw108 mRNA was demonstrated in a few tissues including thymus and brain with the highest expression coming on day 7 in whole embryo followed by relatively consistent expression during development. Cell-surface expression of the CDw108 during T-cell development was further examined by flow cytometry in the human umbilical cord blood and thymus. It was preferentially expressed on a CD34+ stem cell population of umbilical cord blood, and CD3dull CD34+/- CD117 (c-kit)+ CD4bright CDbright cells in the thymus that are involved in the stage of positive selection. These results suggest the contribution of CDw108 in T-cell development, especially in the stage of positive selection in the thymus. |
