| First Author | Ho AS | Year | 1993 |
| Journal | Proc Natl Acad Sci U S A | Volume | 90 |
| Issue | 23 | Pages | 11267-71 |
| PubMed ID | 8248239 | Mgi Jnum | J:16339 |
| Mgi Id | MGI:64423 | Doi | 10.1073/pnas.90.23.11267 |
| Citation | Ho AS, et al. (1993) A receptor for interleukin 10 is related to interferon receptors. Proc Natl Acad Sci U S A 90(23):11267-71 |
| abstractText | We isolated cDNAs encoding a mouse interleukin 10 receptor (mIL-10R) from mouse mast cell and macrophage cell lines. The two cDNAs are substantially identical and express an approximately 110-kDa polypeptide in COS7 cells, which binds mIL-10 specifically. A mouse pro-B-cell line (Ba/F3) expressing transfected recombinant mIL-10R binds IL-10 with high affinity (approximately 70 pM) and proliferates in response to mIL-10. mIL-10R is structurally related to interferon receptors (IFNRs). Since IL-10 inhibits macrophage activation by IFN-gamma, a possible implication of this relationship interaction of IL-10R and IFN-gamma R or their signaling pathways. |
