| First Author | Sims JE | Year | 1988 |
| Journal | Science | Volume | 241 |
| Issue | 4865 | Pages | 585-9 |
| PubMed ID | 2969618 | Mgi Jnum | J:22685 |
| Mgi Id | MGI:70543 | Doi | 10.1126/science.2969618 |
| Citation | Sims JE, et al. (1988) cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science 241(4865):585-9 |
| abstractText | Interleukin-1 alpha and -1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis. A direct expression strategy was used to clone the receptor for IL-1 from mouse T cells. The product of the cloned complementary DNA binds both IL-1 alpha and IL-1 beta in a manner indistinguishable from that of the native T cell IL-1 receptor. The extracellular, IL-1 binding portion of the receptor is 319 amino acids in length and is composed of three immunoglobulin-like domains. The cytoplasmic portion of the receptor is 217 amino acids long. |
