| First Author | Spidale NA | Year | 2018 |
| Journal | Immunity | Volume | 49 |
| Issue | 5 | Pages | 857-872.e5 |
| PubMed ID | 30413363 | Mgi Jnum | J:270295 |
| Mgi Id | MGI:6276541 | Doi | 10.1016/j.immuni.2018.09.010 |
| Citation | Spidale NA, et al. (2018) Interleukin-17-Producing gammadelta T Cells Originate from SOX13(+) Progenitors that Are Independent of gammadeltaTCR Signaling. Immunity 49(5):857-872.e5 |
| abstractText | Lineage-committed alphabeta and gammadelta T cells are thought to originate from common intrathymic multipotent progenitors following instructive T cell receptor (TCR) signals. A subset of lymph node and mucosal Vgamma2(+) gammadelta T cells is programmed intrathymically to produce IL-17 (Tgammadelta17 cells), however the role of the gammadeltaTCR in development of these cells remains controversial. Here we generated reporter mice for the Tgammadelta17 lineage-defining transcription factor SOX13 and identified fetal-origin, intrathymic Sox13(+) progenitors. In organ culture developmental assays, Tgammadelta17 cells derived primarily from Sox13(+) progenitors, and not from other known lymphoid progenitors. Single cell transcriptome assays of the progenitors found in TCR-deficient mice demonstrated that Tgammadelta17 lineage programming was independent of gammadeltaTCR. Instead, generation of the lineage committed progenitors and Tgammadelta17 cells was controlled by TCF1 and SOX13. Thus, T lymphocyte lineage fate can be prewired cell-intrinsically and is not necessarily specified by clonal antigen receptor signals. |
