| First Author | Ford E | Year | 2006 |
| Journal | Genes Dev | Volume | 20 |
| Issue | 9 | Pages | 1075-80 |
| PubMed ID | 16618798 | Mgi Jnum | J:108454 |
| Mgi Id | MGI:3624067 | Doi | 10.1101/gad.1399706 |
| Citation | Ford E, et al. (2006) Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev 20(9):1075-80 |
| abstractText | We investigated the role of SIRT7, one of the seven members of the mammalian sirtuin family. We show that SIRT7 is a widely expressed nucleolar protein that is associated with active rRNA genes (rDNA), where it interacts with RNA polymerase I (Pol I) as well as with histones. Overexpression of SIRT7 increases Pol I-mediated transcription, whereas knockdown of SIRT7 or inhibition of the catalytic activity results in decreased association of Pol I with rDNA and a reduction of Pol I transcription. Depletion of SIRT7 stops cell proliferation and triggers apoptosis. Our findings suggest that SIRT7 is a positive regulator of Pol I transcription and is required for cell viability in mammals. |
