| First Author | Teramoto T | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 28 | Pages | 3909-14 |
| PubMed ID | 18977225 | Mgi Jnum | J:143236 |
| Mgi Id | MGI:3823197 | Doi | 10.1016/j.febslet.2008.10.035 |
| Citation | Teramoto T, et al. (2008) Crystal structure of mSULT1D1, a mouse catecholamine sulfotransferase. FEBS Lett 582(28):3909-14 |
| abstractText | In mammals, sulfonation as mediated by specific cytosolic sulfotransferases (SULTs) plays an important role in the homeostasis of dopamine and other catecholamines. To gain insight into the structural basis for dopamine recognition/binding, we determined the crystal structure of a mouse dopamine-sulfating SULT, mouse SULT1D1 (mSULT1D1). Data obtained indicated that mSULT1D1 comprises of a single alpha/beta domain with a five-stranded parallel beta-sheet. In contrast to the structure of the human SULT1A3 (hSULT1A3)-dopamine complex previously reported, molecular modeling and mutational analysis revealed that a water molecule plays a critical role in the recognition of the amine group of dopamine by mSULT1D1. These results imply differences in substrate binding between dopamine-sulfating SULTs from different species. |
