| First Author | Dong J | Year | 2008 |
| Journal | Biochem Biophys Res Commun | Volume | 366 |
| Issue | 2 | Pages | 551-5 |
| PubMed ID | 18070594 | Mgi Jnum | J:172974 |
| Mgi Id | MGI:5009387 | Doi | 10.1016/j.bbrc.2007.12.002 |
| Citation | Dong J, et al. (2008) Role of modulator recognition factor 2 in adipogenesis and leptin expression in 3T3-L1 cells. Biochem Biophys Res Commun 366(2):551-5 |
| abstractText | The complex network of adipogenic transcription factors regulates adipocyte differentiation, obesity, and insulin resistance. Modulator recognition factor (Mrf) 2 knockout mice exhibit defects in fat accumulation and are protected from diet-induced obesity, suggesting that Mrf2 deficiency affects adipogenesis. Here, we report that the gene expressions of the 2 isoforms of the transcription factors Mrf2, Mrf2alpha, and Mrf2beta, were induced upon adipogenesis in 3T3-L1 cells. Mrf2 mRNA expression was sensitive to stimulation by insulin, dexamethasone, and TNF-alpha in 3T3-L1 preadipocytes and differentiated adipocytes. Down-regulation of Mrf2alpha and Mrf2beta gene expressions induced by small interfering RNAs increased the mRNA expression of leptin. These results indicate that Mrf2 can be a potential regulator of adipocyte differentiation and a potential repressor of leptin. |
