| First Author | Michowski W | Year | 2010 |
| Journal | Biochim Biophys Acta | Volume | 1803 |
| Issue | 9 | Pages | 1043-9 |
| PubMed ID | 20493909 | Mgi Jnum | J:165357 |
| Mgi Id | MGI:4837047 | Doi | 10.1016/j.bbamcr.2010.05.005 |
| Citation | Michowski W, et al. (2010) Morgana/CHP-1 is a novel chaperone able to protect cells from stress. Biochim Biophys Acta 1803(9):1043-9 |
| abstractText | Morgana/CHP-1 (CHORD containing protein-1) has been recently shown to be necessary for proper cell divisions. However, the presence of the protein in postmitotic tissues such as brain and striated muscle suggests that morgana/CHP-1 has additional cellular functions. Here we show that morgana/CHP-1 behaves like an HSP90 co-chaperone and possesses an independent molecular chaperone activity towards denatured proteins. The expression time profile of morgana/Chp-1 in NIH3T3 cells in response to heat stress is similar to that of Hsp70, a classical effector of Heat Shock Factor-1 mediated stress response. Moreover, overexpression of morgana/CHP-1 in NIH3T3 cells leads to the increased stress resistance of the cells. Interestingly, morgana/Chp-1 upregulation in response to transient global brain ischemia lasts longer in ischemia-resistant regions of the gerbil hippocampus than in vulnerable ones, suggesting the involvement of morgana/CHP-1 in natural protective mechanisms in vivo. |
