First Author | Mashimo J | Year | 2000 |
Journal | Gene | Volume | 249 |
Issue | 1-2 | Pages | 99-103 |
PubMed ID | 10831843 | Mgi Jnum | J:62531 |
Mgi Id | MGI:1859057 | Doi | 10.1016/s0378-1119(00)00163-3 |
Citation | Mashimo J, et al. (2000) Genomic structure and chromosomal mapping of the mouse hic-5 gene that encodes a focal adhesion protein. Gene 249(1-2):99-103 |
abstractText | The hic-5 gene encodes a focal adhesion protein that has striking similarity to paxillin. Genomic clones of the mouse hic-5 gene were isolated, and included 10 exons that covered the whole mouse mRNA sequence. Comparison of the sequence with those in the expressed sequence tag database suggested that the hic-5 gene contained an extra exon (named exon 1') located about 1kb upstream of exon 1, and mouse cells seemed to express two alternatively spliced forms of mRNA. All the exon-intron boundaries followed the GT/AG rule. Physical mapping and fluorescent in situ hybridization analysis indicated that the hic-5 gene is located on mouse chromosome 7, 60. 0cM from the centromere. |