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Publication : Genomic structure and chromosomal mapping of the mouse hic-5 gene that encodes a focal adhesion protein.

First Author  Mashimo J Year  2000
Journal  Gene Volume  249
Issue  1-2 Pages  99-103
PubMed ID  10831843 Mgi Jnum  J:62531
Mgi Id  MGI:1859057 Doi  10.1016/s0378-1119(00)00163-3
Citation  Mashimo J, et al. (2000) Genomic structure and chromosomal mapping of the mouse hic-5 gene that encodes a focal adhesion protein. Gene 249(1-2):99-103
abstractText  The hic-5 gene encodes a focal adhesion protein that has striking similarity to paxillin. Genomic clones of the mouse hic-5 gene were isolated, and included 10 exons that covered the whole mouse mRNA sequence. Comparison of the sequence with those in the expressed sequence tag database suggested that the hic-5 gene contained an extra exon (named exon 1') located about 1kb upstream of exon 1, and mouse cells seemed to express two alternatively spliced forms of mRNA. All the exon-intron boundaries followed the GT/AG rule. Physical mapping and fluorescent in situ hybridization analysis indicated that the hic-5 gene is located on mouse chromosome 7, 60. 0cM from the centromere.
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