| First Author | Reimold AM | Year | 2000 |
| Journal | Genes Dev | Volume | 14 |
| Issue | 2 | Pages | 152-7 |
| PubMed ID | 10652269 | Mgi Jnum | J:59916 |
| Mgi Id | MGI:1352298 | Doi | 10.1101/gad.14.2.152 |
| Citation | Reimold AM, et al. (2000) An essential role in liver development for transcription factor XBP-1. Genes Dev 14(2):152-7 |
| abstractText | XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hematopoietic progenitors had no cell-autonomous defect in differentiation. Rather, hepatocyte development itself was severely impaired by two measures: diminished growth rate and prominent apoptosis. Specific target genes of XBP-1 in the liver were identified as alphaFP, which may be a regulator of hepatocyte growth, and three acute phase protein family members. Therefore, XBP-1 is a transcription factor essential for hepatocyte growth. |
